External evaluation of morphine structural model after intravenous bolus administration a) in infants undergoing elective surgery (mean age 21 months)19. b) in children with leukemia undergoing therapeutic lumbar puncture (median age 5.5 years and median weight 20.0 kg)21 c) in neonates (N=10, mean age 1.1 days and mean weight 3.5kg)18 d) in neonates (N=10, mean age 29 days and mean weight 3.9kg)18 e) in infants (N=7, mean age 112 days and 6.2kg)18 f) in infants (N=5, mean age 0.3 years and mean weight 5.3kg)20 g) in children (N=5, mean age 3.7 years and mean weight 16.3kg)20 h) in children (N=4, mean age 6.4 years and mean weight 22.3kg)20