. Author manuscript; available in PMC: 2017 Aug 1.

Published in final edited form as: J Clin Pharmacol. 2016 Feb 22;56(8):1009–1018. doi: 10.1002/jcph.696

Table 2. Population PK parameter estimates for the final model and corresponding bootstrap estimates.

Parameter	Units	FOCE-I		Bootstrap (n=200)
		Point Estimate	BSV	Median	BSV
		95% Confidence Interval	95% Confidence Interval	95% Percentile Interval	95% Percentile Interval
Ka	1/hour	0.751 (0.196, 1.31)		0.732 (0.562, 0.908)
F	%	48.5 (38.9, 58.2)		45.5 (37.9, 53.7)
Vstd^*	Liter	17.8		17.8
CLstd^*	Liter/hour	75.3	58.3% (38.9%, 67.2%)^#	75.3	48.1% (33.1%, 66.0%)
V2std^*	Liter	87.3		87.3
Q2std^*	Liter/hour	136		136
V3std^*	Liter	199		199
Q3std^*	Liter/hour	19.5		19.5
CLmat50^*	weeks	58.3		58.3
HillCL^*		3.6		3.6
Tvol^$	weeks	9.65		9.65
βvol^$		0.614		0.614
Proportional Error		44.9% (35.3%, 54.6%)		47.9% (38.1%, 62.8%)

Parameters were fixed to the estimates in structural IV model^{7, 13}

Parameters were estimated from extracellular water maturation curve¹⁴ and fixed in population pharmacokinetics modeling procedure.

The confidence interval of BSV on CL was calculated based on the BSV on CL and the corresponding SE assuming t-distribution with 88 degrees of freedom.