Table 1.
Participant characteristics by baseline use of antidepressant medications. Data from the Multi-Ethnic Study of Atherosclerosis (MESA).
| SSRIs (n=324) | TCAs (n=88) | SNRIs (n=41) | Other (n=123) | No Antidepressant (n=6298) | |
|---|---|---|---|---|---|
|
| |||||
| Age (years) | 61 | 62 | 60 | 57 | 62 |
|
| |||||
| Male | 30% | 20% | 34% | 41% | 49% |
|
| |||||
| Race/Ethnicity Caucasian | 63% | 58% | 78% | 74% | 36% |
| Chinese | 5% | 3% | 2% | 1% | 12% |
| African-American | 13% | 20% | 2% | 12% | 29% |
| Hispanic | 19% | 18% | 17% | 13% | 22% |
|
| |||||
| Education <High School | 11% | 15% | 7% | 7% | 19% |
| High School | 45% | 56% | 51% | 47% | 47% |
| College | 23% | 11% | 10% | 22% | 17% |
| Graduate School | 21% | 18% | 32% | 25% | 18% |
|
| |||||
| Household Income <$25K | 30% | 37% | 21% | 25% | 32% |
| ≥ $25K and < $50 | 33% | 31% | 21% | 30% | 29% |
| ≥ $50K and < $100 | 24% | 29% | 38% | 28% | 26% |
| ≥ $100K | 13% | 2% | 21% | 17% | 14% |
|
| |||||
| No Health Insurance | 4% | 5% | 12% | 5% | 9% |
|
| |||||
| BMI (kg/m2) | 29 | 30 | 30 | 29 | 28 |
|
| |||||
| Total Cholesterol (mg/dL) | 200 | 192 | 193 | 191 | 194 |
|
| |||||
| HDL Cholesterol (mg/dL) | 54 | 53 | 52 | 52 | 51 |
|
| |||||
| Systolic BP (mmHG) | 124 | 124 | 130 | 121 | 127 |
|
| |||||
| C-reactive protein (mg/dl) | 4.9 | 6.1 | 4.4 | 4.2 | 3.7 |
|
| |||||
| Fibrinogen Antigen (mg/dl) | 346 | 360 | 342 | 337 | 347 |
|
| |||||
| IL-6 (pg/mL) | 1.67 | 1.95 | 1.76 | 1.54 | 1.54 |
|
| |||||
| Depression Score (CES-D) | 11 | 10 | 11 | 12 | 7 |
|
| |||||
| Anxiety Score (STAI) | 18 | 17 | 18 | 19 | 16 |
|
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| Smoking: Current | 12% | 19% | 17% | 20% | 13% |
| Former | 42% | 40% | 44% | 43% | 36% |
|
| |||||
| Alcohol Consumption: Current | 57% | 50% | 66% | 50% | 55% |
| Former | 28% | 27% | 24% | 39% | 24% |
|
| |||||
| Intentional Exercise (met-min/wk) | 1680 | 1312 | 1119 | 1474 | 1548 |
|
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| Diabetes | 13% | 16% | 10% | 8% | 13% |
|
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| Lipid Lowering Medications | 23% | 25% | 34% | 23% | 16% |
|
| |||||
| Antihypertensive Medications | 39% | 50% | 37% | 38% | 37% |
|
| |||||
| Aspirin Use | 26% | 24% | 39% | 32% | 25% |
|
| |||||
| Coronary Artery Calcium | |||||
| Prevalent CAC>0 | 46% | 44% | 51% | 37% | 50% |
| incident CAC>0 | 28% | 23% | 14% | 26% | 26% |
|
| |||||
| ABI Baseline | 1.12 | 1.12 | 1.11 | 1.14 | 1.11 |
| Change E1 to E5 | -0.014 | -0.016 | -0.024 | -0.005 | -0.007 |
|
| |||||
| Carotid IMT (mm) Baseline | 0.74 | 0.73 | 0.67 | 0.70 | 0.76 |
| Change E1 to E5 | 0.11 | 0.13 | 0.10 | 0.10 | 0.11 |
IL-6= Interleukin-6; CES-D: Center for Epidemiologic Studies Depression Scale; STAI=Spielberger Trait Anxiety; CCA=Common Carotid Artery; IMT=Intima-Media Thickness; ABI=Ankle-Brachial Index.