Table 2.

Final population PK model parameter estimates and bootstrap results.

	Final Model		Bootstrap (n=1000)
Population PK Parameters	Estimate	%SE	Median	95% CI
CLtypical (L/h)1	0.130	4.6	0.129	0.116 – 0.142
Exponent for Agev effect	0.22	11.5	0.22	0.17 – 0.26
Vtypical (L)2	2.96	4.9	2.94	2.67 – 3.25
Interindividual variability
CL, %CV	31.9	26.0	31.6	22.7 – 40.7
V, %CV	18.8	149	18.8	3.3 – 45.7
Residual variability, %CV	18.4	26.8	17.6	12.2 – 24.7

CL, clearance; V, volume of distribution; %CV, coefficient of variation × 100; %SE, relative standard error × 100; 95% CI, Bootstrap parameter estimate at the 2.5th and 97.5th percentiles.

¹$C{L}_{(L∕h)}=0.13\times {\left(\frac{Weight}{5.8\mathrm{kg}}\right)}^{0.75}\times {\left(\frac{Age}{0.4year}\right)}^{0.22}$

²$V_{\left(L\right)}=2.96\times \left(\frac{Weight}{5.8\mathrm{kg}}\right)$