Table 3.

Optimized Aminophylline Maintenance Dosing Regimens based on Monte Carlo Simulations

	Age
	1 month	6 month	1 year	2 year	6 year	10 year
Intermittent Dosing every 6 h
Intermittent Dose a	1.0 mg/kg	1.4 mg/kg	1.6 mg/kg	1.6 mg/kg	1.8 mg/kg	1.8 mg/kg
TroughSS, mg/L
Median	6.9	7.4	7.4	6.8	6.6	6.6
90% Rangeb	3.7 – 12.9	3.7 – 13.6	3.8 – 13.9	3.5 – 12.9	3.3 – 12.6	3.3 – 12.6
% TroughSS 5-10 mg/L	65%	61%	63%	61%	61%	61%
% TroughSS >20 mg/L	0.1%	0.5%	0.5%	0.4%	0.4%	0.4%
Continuous Infusion
Infusion Rate	0.16 mg/kg/h	0.20 mg/kg/h	0.22 mg/kg/h	0.22 mg/kg/h	0.26 mg/kg/h	0.26 mg/kg/h
CSS, mg/L
Median	7.2	7.1	7.2	6.7	6.8	6.8
90% Rangec	4.0 – 13.1	4.0 – 13.6	3.7 – 12.8	3.5 – 11.9	3.6 – 11.9	3.6 – 11.9
% CSS 5-10 mg/L	65%	68%	65%	61%	64%	64%
% CSS >20 mg/L	0.3%	0.3%	<0.1%	<0.1%	<0.1%	<0.1%

^aDose given intravenous over 30 minutes every 6 hours

^bRange in which 90% of concentrations from 1000 simulated children fell

Trough_SS, trough serum concentration at steady-state

C_SS, serum concentration at steady-state