Table 1.
CC50 values of methanolic and aqueous extracts of garlic on peritoneal macrophage cells and their IC50 and selectivity index (SI) values against promastigote forms of L. tropica
| Samples | ICc50 (μg/ml) | CCb50 (μg/ml) | SId |
|---|---|---|---|
| Methanolic extract | 12.3 ± 1.15 | 291.4 ± 3.08 | 23.7 |
| Aqueous extract | 19.2 ± 2.51 | 348.2 ± 4.6 | 18.1 |
| MAa | 15.4 ± 2.51 | 283.6 ± 4.6 | 18.4 |
Data are expressed as the mean ± SD (n = 3)
aMeglumine antimoniate (MA, Glucantime) as a control drug
bConcentration of extracts that caused 50 % mortality in BALB/c mice peritoneal macrophages
cConcentration of extracts that caused 50 % inhibitory in promastigote forms of L. tropica
dSelectivity index (CC50/IC50)