Table 2.

Estimated concentrations (in mM) of metabolites, lipids and macromolecules obtained from LCModel fittings of HRMAS ¹H NMR spectra of prostate samples

Metabolites	Untreated-benign prostate tissue	Untreated prostate cancer tissue	Degarelix treated prostate cancer tissue
	mean ± SEM	mean ± SEM	mean ± SEM
Alanine	1.13 ± 0.24	2.48 ± 0.18	2.09 ± 0.23
Acetate	3.04 ± 1.07	5.32 ± 1.58	3.19 ± 1.13
Choline (Cho)	1.62 ± 0.40	2.95 ± 0.73	1.43 ± 0.32
Creatine (Cr)	1.73 ± 0.29	1.59 ± 0.35	2.02 ± 0.43
Glutamine (Glu)	7.43 ± 2.74	13.90 ± 5.61	3.79 ± 1.66
Glutamate (Gln)	5.51 ± 1.32	11.20 ± 3.06	5.12 ± 0.72
Glycine	1.25 ± 0.18	1.56 ± 0.00	1.95 ± 0.27
PCh + GPC	1.74 ± 0.21	3.32 ± 0.66	2.81 ± 0.28
Myo-inositol	9.17 ± 1.84	10.75 ± 2.10	7.79 ± 1.04
Lactate	15.59 ± 1.90	23.31 ± 2.54	15.21 ± 1.89
Lysine	4.44 ± 1.68	8.32 ± 3.25	2.20 ± 0.52
Phosphoethanolamine (PE)	15.38 ± 6.44	32.70 ± 13.35	8.99 ± 5.35
Scyllo-Inositol	2.34 ± 0.86	3.94 ± 1.37	1.34 ± 0.32
Taurine	6.40 ± 1.19	7.76 ± 1.29	6.02 ± 0.43
Phospho-Creatine (PCr)	1.63 ± 0.48	2.15 ± 0.81	1.05 ± 0.07
Citrate	5.82 ± 2.00	2.20 ± 1.05	3.05 ± 0.63
t-choline (Cho + GPC + PCh)	3.14 ± 0.38	5.66 ± 0.68	3.48 ± 0.51
t-creatine (Cr + PCr)	2.59 ± 0.36	3.06 ± 0.52	2.15 ± 0.32
Glu + Gln	12.66 ± 3.91	24.59 ± 8.31	8.62 ± 1.34
Lipids and macromolecules (MM)
Lipid 0.9 ppm	28.92 ± 3.93	31.48 ± 7.61	16.10 ± 4.34
MM 0.9 ppm	66.48 ± 0.00	10.56 ± 0.00	13.61 ± 1.51
Lipid 2.0 ppm	164.55 ± 101.44	206.02 ± 101.84	21.11 ± 12.04
MM 2.0 ppm	72.99 ± 18.43	114.85 ± 40.39	59.05 ± 22.04
Lip 1.5 ppm	1420.01 ± 229.64	1781.03 ± 682.35	544.69 ± 367.80
MM 1.4 ppm	5.50 ± 1.88	9.98 ± 2.03	9.84 ± 4.19
MM 1.7 ppm	243.13 ± 129.43	226.36 ± 165.19	60.00 ± 35.75
Polyamines	162.53 ± 65.74	191.87 ± 87.74	50.96 ± 9.56
Lipid 1.3 ppm	42.70 ± 6.77	55.42 ± 13.08	33.10 ± 8.77

SEM standard error mean, PCh phosphocholine, GPC glycerophosphocholine