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. 2016 Jan 4;18:627–635. doi: 10.1007/s11307-015-0921-x

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© The Author(s) 2015

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 2 — The effects of different ACF-margins prior to scatter scaling estimation on reconstructed activity concentrations (summed from frame 5 to the last frame), illustrated for typical a (R)-[¹¹C]verapamil, b [¹¹C]raclopride and c [¹¹C]flumazenil scans in coronal (left panel) and sagittal views (middle panel). The ratio images (right panel) show the ratios of reconstructed activity concentration images without an ACF-margin to those obtained using a 10-mm ACF-margin. The red arrows show an area where a prominent artefact caused by a mismatch between emission and transmission data was located. The blue arrows indicate the same area. A significant increment in reconstructed activity concentrations was observed when a 10-mm ACF-margin was applied.