Table 3.

Univariable and multivariable analysis of influence of waiting time on disease-free survival and overall survival in patients treated with neoadjuvant therapy followed by esophagectomy for esophageal cancer

	Univariable analysis			Multivariable analysis
	HR	95 % CI	p value	HR	95 % CI	p value
Disease-free survival
Additional week waiting time	0.96	0.88–1.05	0.362	0.96	0.88–1.04	0.312
ypT stage
T0	Reference	–	–	Reference
T1-2	1.55	0.69–3.47	0.288	1.22	0.54–2.79	0.635
T3-4a	3.94	1.89–8.25	<0.001	2.40	1.10–5.22	0.028
ypN stage
N0	Reference	–	–	Reference	–	–
N1	1.83	1.11–3.03	0.019	1.72	1.03–2.88	0.039
N2-3	4.42	2.77–7.03	<0.001	3.09	1.81–5.25	<0.001
Radicality
R0	Reference	–	–	Reference	–	–
R1	4.41	2.46–7.91	<0.001	1.93	1.00–3.70	0.049
Overall survival
Additional week waiting time	1.00	0.91–1.08	0.910	0.96	0.88–1.05	0.372
ypT stage
T0	Reference	–	–	Reference	–	–
T1-2	0.95	0.45–2.02	0.895	0.71	0.33–1.54	0.385
T3-4a	2.54	1.31–4.94	0.006	1.46	0.71–3.00	0.300
ypN stage
N0	Reference	–	–	Reference	–	–
N1	2.07	1.25–3.43	0.005	2.04	1.21–3.43	0.007
N2-3	4.15	2.57–6.69	<0.001	3.04	1.74–5.33	<0.001
Radicality
R0	Reference	–	–	Reference	–	–
R1	4.40	2.46–7.87	<0.001	1.90	0.99–3.66	0.055

HR hazard ratio, CI confidence interval

Analysis was performed using Cox regression model. Bold values indicate statistically significant results (e.g., p < 0.05). Only waiting time and variables with p < 0.1 from univariable analysis are reported and were used for multivariable analysis