Table 4.

Univariable and multivariable analysis of influence of waiting time on disease-free survival and overall survival in patients treated with primary surgery for esophageal cancer

	Univariable analysis			Multivariable analysis
	HR	95 % CI	p value	HR	95 % CI	p value
Disease-free survival
Additional week waiting time	0.97	0.91	0.222	1.03	0.95	0.443
ASA score
1	Reference	–	–	Reference	–	–
2	0.63	0.37–1.09	0.100	0.95	0.53–1.72	0.876
≥3	0.54	0.27–1.07	0.075	0.95	0.32–1.39	0.284
Surgical approach
Transthoracic	Reference	–	–	Reference	–	–
Transhiatal	0.50	0.29–0.86	0.012	0.66	0.36–1.22	0.182
pT stage
T0-2	Reference	–	–	Reference	–	–
T3-4a	4.08	2.02–8.26	<0.001	2.51	1.13–5.57	0.024
pN stage
N0	Reference	–	–	Reference	–	–
N1	2.89	1.35–6.20	0.006	2.25	1.00–5.05	0.029
N2-3	5.20	2.58–10.50	<0.001	2.92	1.33–6.45	0.008
Radicality
R0	Reference	–	–	Reference	–	–
R1	2.95	1.67–5.21	<0.001	1081	0.97–3.37	0.063
Additional year date diagnosis	0.88	0.81–0.97	0.009	0.94	0.85–1.05	0.266
Overall survival
Additional week waiting time	0.99	0.95–1.05	0.803	1.06	0.99–1.13	0.108
Tumor location
Middle esophagus	Reference	–	–	Reference	–	–
Distal esophagus	0.68	0.37–1.24	0.211	0.54	0.28–1.03	0.060
Gastro-esophageal junction	1.74	0.96–3.15	0.067	1.12	0.60–2.09	0.728
pT stage
T0-2	Reference	–	–	Reference	–	–
T3-4a	2.95	1.62–5.38	<0.001	1.86	0.92–3.78	0.086
pN stage
N0	Reference	–	–	Reference	–	–
N1	2.89	1.52–5.49	0.001	2.76	1.40–5.45	0.004
N2-3	3.25	1.78–5.94	<0.001	2.37	1.16–4.84	0.018
Radicality
R0	Reference	–	–	Reference	–	–
R1	2.65	1.56–4.51	<0.001	2.08	1.17–3.70	0.013
Additional year date diagnosis	0.92	0.84–1.01	0.070	0.97	0.88–1.08	0.584

Analysis was performed using Cox regression model. Bold values indicate statistically significant results (e.g., p < 0.05). Only waiting time and variables with p < 0.1 from univariable analysis are reported and were used for multivariable analysis

ASA American Society of Anesthesiologists, HR hazard ratio, CI confidence interval