Table 6.

Univariable analysis of influence of waiting time on disease-free survival and overall survival in patients treated with esophagectomy for esophageal cancer

	Disease-free survival			Overall survival
	HR	95 % CI	p value	HR	95 % CI	p value
Univariable analysis
Additional week waiting time	0.97	0.91–1.02	0.222	0.99	0.95–1.05	0.803
Age at diagnosis	0.98	0.96–1.01	0.129	1.00	0.98–1.02	0.876
Gender
Female	Reference	–	–	Reference	–	–
Male	1.27	0.75–2.16	0.379	1.02	0.63–1.66	0.932
ASA classification
1	Reference	–	–	Reference	–	–
2	0.63	0.37–1.09	0.100	0.93	0.54–1.59	0.782
>3	0.54	0.27–1.07	0.075	0.98	0.53–1.83	0.984
Tumor location
Middle esophagus	Reference	–	–	Reference	–	–
Distal esophagus	0.25	0.36–1.30	0.246	0.68	0.37–1.24	0.211
Gastro-esophageal junction	0.18	0.82–2.89	0.177	1.74	0.96–3.15	0.067
Surgical approach
Transthoracic	Reference	–	–	Reference	–	–
Transhiatal	0.50	0.29–0.86	0.012	0.77	0.48–1.24	0.285
Histological type
Adenocarcinoma	Reference	–	–	Reference	–	–
Squamous cell carcinoma	0.74	0.43–1.26	0.264	0.93	0.57–1.49	0.748
Other	3.33	0.45–24.45	0.238	3.37	0.46–24.77	0.233
pT stage
T0-2	Reference	–	–	Reference	–	–
T3-4a	4.08	2.02–8.26	<0.001	2.95	1.62–5.38	<0.001
pN stage
N0	Reference	–	–	Reference	–	–
N1	2.89	1.35–6.20	0.006	2.89	1.52–5.49	0.001
N2-3	5.20	2.58–10.50	<0.001	3.25	1.78–5.94	<0.001
Radicality
R0	Reference	–	–	Reference	–	–
R1	2.95	1.67–5.21	<0.001	2.65	1.56–4.51	<0.001
Referral
By general practitioner	Reference	–	–	Reference	–	–
By another hospital	1.50	0.82–2.75	0.190	1.00	0.60–1.67	0.999
Additional year date diagnosis	0.88	0.81–0.97	0.009	0.92	0.84–1.01	0.070

Analysis was performed using Cox regression model

ASA American Society of Anesthesiologists, HR hazard ratio, CI confidence interval