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. 2015 Dec 4;18:588–597. doi: 10.1007/s11307-015-0917-6

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© The Author(s) 2015

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — Images of rat brain (sagittal views, animals anesthetized with isoflurane). a MRI template. Brain regions are indicated by the following abbreviations: bu bulbus olfactorius, ce cerebellum, co cortex, hi hippocampus, hy hypothalamus, mb midbrain, p,m pons and medulla, s striatum, and t thalamus. b MicroPET image of young rat (age 3 months) superimposed on the MRI template. c MicroPET image of old rat (age 18 months) superimposed on this template. Frames from 22 to 74 min were summed (since early frames may contain a significant contribution of radioactivity in the blood pool), and a plane was chosen about 1.6 mm from the midline. Note the high uptake in the pons and medulla of the young rat whereas the distribution of radioactivity in the brain of the old rat is more uniform.