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Radiochromatograms of rat plasma. Samples were drawn at different intervals after intravenous injection of [11C]SA4503: 5 min (a), 10 min (b), 20 min (c), 40 min (d), and 60 min (e). Eluate radioactivity (in CPM) is plotted against retention time on the HPLC column. The radioactive peak with 8-min retention time is the parent compound; radioactive species eluting between 4 and 6 min are metabolites.
