Table 2.

Biodistribution of [¹¹C]SA4503 (90 min after injection)

	SUV			T/P ratio
Tissue	Young (n = 16)	Aged (n = 13)	P value	Young (n = 16)	Aged (n = 13)	P value
Cerebellum	1.31 ± 0.09	1.33 ± 0.10	ns	12.70 ± 1.37	8.23 ± 1.00	<0.05
Cerebral cortex	1.30 ± 0.08	1.56 ± 0.11	ns	12.43 ± 1.06	9.66 ± 1.11	ns
Rest brain	1.75 ± 0.10	1.36 ± 0.09	<0.05	16.79 ± 1.52	8.45 ± 0.98	<0.001
Adipose tissue	0.47 ± 0.06	0.28 ± 0.06	ns	4.40 ± 0.56	1.66 ± 0.36	ns
Bladder	1.30 ± 0.20	2.34 ± 0.73	ns	13.04 ± 2.63	14.67 ± 5.14	ns
Bone	0.46 ± 0.05	0.43 ± 0.05	ns	4.19 ± 0.49	2.58 ± 0.31	ns
Bone marrow	2.29 ± 0.91	3.15 ± 0.73	ns	20.97 ± 8.38	17.67 ± 3.57	ns
Heart	0.36 ± 0.03	0.65 ± 0.04	ns	3.51 ± 0.44	3.92 ± 0.39	ns
Large intestine	1.91 ± 0.10	2.20 ± 0.16	ns	18.17 ± 1.53	13.51 ± 1.55	ns
Small intestine	2.29 ± 0.22	3.18 ± 0.26	ns	22.08 ± 2.96	19.49 ± 2.26	ns
Kidney	4.40 ± 0.23	3.50 ± 0.21	ns	42.00 ± 3.47	21.30 ± 1.89	<0.001
Liver	9.30 ± 0.39	10.78 ± 0.47	ns	87.37 ± 5.45	65.30 ± 5.37	<0.001
Lung	2.07 ± 0.11	2.24 ± 0.16	ns	19.69 ± 1.69	13.61 ± 1.38	ns
Muscle	0.17 ± 0.02	0.35 ± 0.06	ns	1.76 ± 0.27	2.13 ± 0.43	ns
Pancreas	5.18 ± 0.51	5.63 ± 0.59	ns	48.46 ± 5.86	34.75 ± 4.99	ns
Plasma	0.11 ± 0.01	0.17 ± 0.01	ns	1.00	1.00	ns
Red blood cells	0.06 ± 0.01	0.09 ± 0.01	ns	0.63 ± 0.07	0.50 ± 0.06	ns
Spleen	2.47 ± 0.17	4.45 ± 0.30	<0.01	23.52 ± 2.11	27.28 ± 2.81	ns
Submandibular gland	3.29 ± 0.25	5.98 ± 0.59	<0.001	30.82 ± 2.72	36.20 ± 4.58	ns
Urine	1.58 ± 0.28	3.32 ± 1.22	<0.05	14.51 ± 2.67	21.33 ± 8.50	ns