Table 1.
In vitro antimicrobial susceptibility patterns of Nocardia in CF patients.
| MIC, μg/mL (broth microdilution) | ||||||||
|---|---|---|---|---|---|---|---|---|
| Antimicrobial agent |
N. farcinica |
N. transvalensis |
N. veterana | N. pneumoniae | N. wallacei | |||
| Patient 1 | Patient 2 | Patient 3 | Patient 4 | Patient 5 | Patient 6 | Patient 7 | Patient 8 | |
| Amikacin | ≤4 | ≤4 | ≤4 | 16 | 16 | ≤4 | ≤4 | >8 |
| Tobramycin | >4 | >4 | >4 | >4 | >4 | 4 | 2 | >8 |
| Cefotaxime | >16 | >16 | >16 | 2 | 2 | 0.5 | 1 | 4 |
| Amoxicillin-clavulanic | 8/4 | 8/4 | 8/4 | ≤4/2 | 8/4 | ≤4/2 | ≤4/2 | 8/4 |
| Imipenem | 8 | 8 | 8 | 8 | 8 | 0.25 | 1 | 16 |
| Ciprofloxacin | >2 | >2 | >2 | 0.25 | 0.5 | >2 | >2 | <0.25 |
| Trimethoprim-sulfamethoxazole | 0.5/9.5 | >2/38 | 0.5/9.5 | 2/38 | 0.5/9.5 | 1/19 | 0.5/9.5 | >4/76 |
| Gentamicin | >16 | >16 | >16 | >16 | >16 | ≤4 | ≤4 | >16 |