Table 2.
Characteristics of CF patients.
| Patient code | Age (years)/sex | Nocardia species | Accompanying pathogens | Clinical significance | Antibiotic treatment | Clinical evolution |
|---|---|---|---|---|---|---|
| 1 | 11/F | N. farcinica | S. aureus, H. influenzae | Chronic colonizationa, pneumonia | TMP-SMX, AMC | Bronchiectasis |
| 2 | 17/F | N. farcinica | P. aeruginosa, S. apiospermum | Colonization | TMP-SMX | No worsening |
| 3 | 10/F | N. farcinica | S. aureus, P. aeruginosa | Pneumonia | AMK, TMP-SMX | Severe bronchiectasis. Worsening |
| 4 | 11/M | N. transvalensis | S. aureus, P. aeruginosa | Chronic colonization | TMP-SMX | Dead 1998. Massive hemoptysis |
| 5 | 10/F | N. transvalensis | S. aureus, P. aeruginosa | Chronic colonization | TMP-SMX | Severe bronchiectasis. Worsening |
| 6 | 16/M | N. veterana | S. aureus, P. aeruginosa | Transient colonizationb | None | No worsening |
| 7 | 15/F | N. pneumoniae | S. aureus, S. apiospermum | Transient colonization | None | No worsening |
| 8 | 16/F | N. wallacei | P. aeruginosa, A. fumigatus | Transient colonization | AMC | No worsening |
F, female; M, male; TMP-SMX, trimethoprim-sulfamethoxazole; AMC, amoxicillin-clavulanic acid; AMK, amikacin.
a
Chronic colonization: Nocardia detected three or more times in six months.
b
Transient colonization: Nocardia detected occasionally in one or two cultures in six months.