Table 1.
Demographical and clinical data of the study groups based on neuropsychological assessment
| Demographical and | NC (1) | MCI-PD (2) | MCI-AD 3) | P-value | |
| clinical data | N = 25 | N = 13 | N = 19 | (chi-square) | |
| Female (%) | 9 (36) | 3 (23) | 11 (58) | 1 vs. 2 = .656n.s. | |
| 1 vs. 3 = .255n.s | |||||
| 2 vs. 3 = .110n.s | |||||
| ANOVA | Post hoc p-value | ||||
| P-values | (Tukey) (Games Howell for | ||||
| P-tau and T-tau) | |||||
| Age (SD, range) | 63.6 (7.2, 52–77) | 67.2 (4.1, 61–73) | 66.7 (4.9, 58–76) | 0.123 | 1 vs. 2 = .187n.s. |
| 1 vs. 3 = 0.217n.s | |||||
| 2 vs. 3 = 0.964n.s | |||||
| Education (SD, range) | 13.6 (3.4, 8–18) | 11.5 (2.8, 8–16) | 13.9 (3.0, 7–18) | 0.153 | 1 vs. 2 = 0.733n.s. |
| 1 vs. 3 = 0.129n.s | |||||
| 2 vs. 3 = 0.433n.s | |||||
| MMSE (SD, range) | 29.1 (0.8, 28–30) | 28.5 (1.2, 26–30) | 27.3 (1.6, 23–30) | 0.001 | 1 vs. 2 = 0.129n.s. |
| 1 vs. 3 = 0.001** | |||||
| 2 vs. 3 = 0.023* | |||||
| Aβ42, ng/l (SD, range) | 1084.7 | 874.8 | 518.4 | 0.001 | 1 vs. 2 = 0.001** |
| (198.3, 772–1500) | (153.1, 707–1280) | (105.7, 302–726) | 1 vs. 3 = 0.001** | ||
| 2 vs. 3 = 0.001** | |||||
| P-tau, ng/l (SD, range) | 48.2 | 48.0 | 107.0 | 0.001 | 1 vs. 2 = 0.857n.s. |
| (13.5, 26–70) | (34.9, 25–155) | (49.0, 54–238) | 1 vs. 3 = 0.001** | ||
| 2 vs. 3 = 0.001** | |||||
| T-tau, ng/l (SD, range) | 296.0 | 262.5 | 578.3 | 0.001 | 1 vs. 2 = 0.655n.s. |
| (103.4, 114–453) | (130.7, 119–566) | (338.1, 248–1407) | 1 vs. 3 = 0.001** | ||
| 2 vs. 3 = 0.001** | |||||
| Neuropsychological tests – | |||||
| raw scores (SD, range) | |||||
| RAVLT learning trial 1–5 | 45.3 (8.6, 30–61) | 36.2 (9.3, 18–47) | 28.3 (8.5, 14–42) | 0.001 | 1 vs. 2 = 0.010** |
| 1 vs. 3 = 0.001** | |||||
| 2 vs. 3 = 0.039* | |||||
| RAVLT delayed recall | 9.0 (2.1, 5–13) | 6.3 (2.5, 3–12) | 2.8 (2.9, 0–9) | 0.001 | 1 vs. 2 = 0.007** |
| 1 vs. 3 = 0.001** | |||||
| 2 vs. 3 = 0.001** | |||||
| RCFT delayed recall | 9.4 (6.1, 1–20) | 5.9 (4.1, 0–19) | 0.059 (t-test) | ||
| COWAT | 41.4 (8.6, 23–59) | 30.1 (9.8, 18–49) | 36.5 (13.6, 6–63) | 0.012 | 1 vs. 2 = 0.009** |
| 1 vs. 3 = 0.302n.s | |||||
| 2 vs. 3 = 0.233n.s | |||||
| TMT B | 82.3 (35.8, 40–159) | 207.6 (93.1, 75–349) | 150.3 (114.7, 60–531) | 0.001 | 1 vs. 2 = 0.001** |
| 1 vs. 3 = 0.029* | |||||
| 2 vs. 3 = 0.149n.s | |||||
| Stroop Color-Word | 57.2 (15.6, 19–94) | 80.3 (17.9, 55–110) | 94.8 (77.9, 53–400) | 0.034 | 1 vs. 2 = 0.316n.s |
| 1 vs. 3 = 0.029** | |||||
| 2 vs. 3 = 0.667n.s | |||||
| RCFT copy trial | 27.1 (9.7, 3–35) | 28.1 (7.2, 5–35) | 0.740 (t-test) | ||
| Neuropsychological tests – | |||||
| T scores (SD, range) | |||||
| RAVLT learning trial 1–5 | 52.8 (11.8, 35–82) | 42.5 (12.8, 17–62) | 32.6 (9.8, 16–46) | 0.001 | 1 vs. 2 = 0.029* |
| 1 vs. 3 = 0.001** | |||||
| 2 vs. 3 = 0.055n.s | |||||
| RAVLT delayed recall | 51.6 (9.1, 37–75) | 42.8 (8.3, 31–60) | 30.7 (10.2, 21–51) | 0.001 | 1 vs. 2 = 0.0.21* |
| 1 vs. 3 = 0.001** | |||||
| 2 vs. 3 = 0.002** | |||||
| RCFT delayed recall | 37.2 (14.7, 20–62) | 28.3 (7.1, 20–42) | 0.029* (t-test) | ||
| COWAT | 50.7 (6.8, 37–64) | 43.2 (8.2, 33–58) | 48.6 (14.5, 21–79) | 0.109 | 1 vs. 2 = 0.091n.s. |
| 1 vs. 3 = 0.782n.s | |||||
| 2 vs. 3 = 0.315n.s | |||||
| TMT B | 52.1 (9.7, 35–68) | 28.8 (16.2, 10–52) | 40.4 (12.2, 10–57) | 0.001 | 1 vs. 2 = 0.001** |
| 1 vs. 3 = 0.010** | |||||
| 2 vs. 3 = 0.031* | |||||
| Stroop Color-Word | 55.8 (9.2, 37–77) | 44.5 (10.2, 27–57) | 43.6 (13.6, 10–60) | 0.001 | 1 vs. 2 = 0.011** |
| 1 vs. 3 = 0.002** | |||||
| 2 vs. 3 = 0.972n.s | |||||
| RCFT copy trial | 44.1 (11.3, 23–63) | 44.3 (9.8, 23–63) | 0.950 (t-test) | ||