. 2015 Oct 27;49(4):971–990. doi: 10.3233/JAD-150538

Table 3.

Change from baseline in cognitive measures

		Week 6			Week 12
Endpoint	Baseline Score (Mean ± SEM)	change from baseline	p value (between groups)	Effect Size Cohen’s d (95% C.I.)	change from baseline	p value (between groups)	Effect Size Cohen’s d (95% C.I.)	Total Treatment p value
Cognitive TMT-B (ms^–1)
MMFS-01	10.6 ± 1.0	2.0 ± 0.8	0.066	0.58 (–0.03–1.17)	2.1 ± 0.8	0.116	0.51 (–0.10–1.10)	0.047^*
Placebo	11.2 ± 0.9	0.1 ± 0.5	0.066	0.58 (–0.03–1.17)	0.2 ± 0.8	0.116	0.51 (–0.10–1.10)	0.047^*
DigitSpan (consecutive #s)
MMFS-01	11.52 ± 0.59	1.61 ± 0.48	0.023^*	0.61 (–0.01–1.20)	1.43 ± 0.55	0.225	0.30 (–0.3–0.89)	0.064
Placebo	11.05 ± 0.50	0.10 ± 0.59	0.023^*	0.61 (–0.01–1.20)	0.67 ± 0.54	0.225	0.30 (–0.3–0.89)	0.064
Flanker: –1(Incongruent - Congruent) (s)
MMFS-01	0.13 ± 0.03	0.04 ± 0.03	0.964	0.27 (–0.89–0.35)	0.05 ± 0.03	0.440	0.15 (–0.76–0.47)	0.660
Placebo	0.09 ± 0.02	0.01 ± 0.02	0.964	0.27 (–0.89–0.35)	0.03 ± 0.02	0.440	0.15 (–0.76–0.47)	0.660
Face-Name (d’)
MMFS-01	1.70 ± 0.14	0.12 ± 0.16	0.484	0.10 (–0.51–0.72)	0.64 ± 0.19	0.089	0.44 (–0.18–1.05)	0.103
Placebo	1.57 ± 0.14	0.04 ± 0.18	0.484	0.10 (–0.51–0.72)	0.25 ± 0.19	0.089	0.44 (–0.18–1.05)	0.103
Overall Cognitive Ability ( $\bar{z}$ )
MMFS-01	–0.025 ± 0.12	0.41 ± 0.12	0.017^*	0.74 (0.12–1.34)	0.60 ± 0.13	0.003^**	0.91 (0.27–1.51)	0.001^**
Placebo	–0.002 ± 0.11	0.06 ± 0.08	0.017^*	0.74 (0.12–1.34)	0.03 ± 0.14	0.003^**	0.91 (0.27–1.51)	0.001^**

Mean ± SEM. ^*significant p < 0.05. ^**significant p < 0.01.