Table 4.

Change from baseline in emotional and sleep measures

		Week 6			Week 12
Endpoint	Baseline Score	change from baseline	p value (change from baseline)	p value (between group difference)	change from baseline	p value (change from baseline)	p value (between group difference)
Emotional
HAM-A
MMFS-01	17.1 ± 3.0	–6.3 ± 3.6	<0.001***	0.876	–7.3 ± 5.8	<0.001***	0.396
Placebo	17.2 ± 2.5	–6.1 ± 3.4	<0.001***		–8.6 ± 4.1	<0.001***
PANAS: Positive Affect
MMFS-01	28.3 ± 6.6	4.7 ± 5.2	<0.001***	0.648	3.9 ± 7.0	0.014*	0.596
Placebo	27.7 ± 8.1	3.8 ± 8.1	0.046*		5.1 ± 8.2	0.01*
PANAS: Negative Affect
MMFS-01	24.8 ± 6.4	–7.6 ± 7.5	<0.001***	0.556	–8.3 ± 8.9	0.001**	0.371
Placebo	23.9 ± 6.0	–6.3 ± 5.9	<0.001***		–6.4 ± 9.0	0.008**
Sleep
PSQI
MMFS-01	13.7 ± 2.6	–4.2 ± 3.8	<0.001***	0.415	–4.8 ± 4.5	<0.001***	0.279
Placebo	12.9 ± 2.4	–3.2 ± 3.7	<0.001***		–6.1 ± 3.3	<0.001***

Mean ± SEM. ^*significant p <  0.05. ^**significant p <  0.01. ^***significant p <  0.001.