Fig.4.
Effectiveness of the oligomeric Aβ1-42-induced NBM lesion model and effects in mock and immunized mice. All mice consistently showed less cortical cholinergic fiber density on the Aβ injected side of the brain, as compared to the scrambled-Aβ (Aβscr) injected control side of the brain (A). Compared to mock mice, immunized mice showed significantly reduced cholinergic fiber loss in the cortex, as measured by optical fiber density after ChAT immunostaining (B). In both panels the error bars represent SEM.