Table 1.
Visit -6 | Visit -5 | Visit -4 | Visit -3 | Visit -2 | Visit -1 | Visit 0 | ||||||||
NC-NC | NC-MCI | NC-NC | NC-MCI | NC-NC | NC-MCI | NC-NC | NC-MCI | NC-NC | NC-MCI | NC-NC | NC-MCI | NC-NC | NC-MCI | |
Sample size | 21 | 2 | 48 | 8 | 49 | 14 | 52 | 18 | 58 | 25 | 60 | 27 | 60 | 27 |
Y prior | – 12.56 | – 12.79 | – 10.78 | – 10.98 | – 8.53 | – 8.83 | – 6.45 | – 6.72 | – 4.30 | – 4.45 | – 2.00 | – 2.22 | 0 | 0 |
to MCI Dx | (0.43) | (0.29) | (0.63) | (0.43) | (0.40) | (0.39) | (0.47) | (0.64) | (0.49) | (0.57) | (0.25) | (0.51) | (0.00) | (0.00) |
Age | 65.71 | 66.50 | 67.73 | 68.13 | 70.02 | 69.21 | 72.25 | 71.17 | 74.33 | 73.72 | 76.67 | 75.96 | 78.67 | 78.11 |
(4.24) | (0.71) | (4.22) | (4.76) | (4.25) | (4.49) | (4.16) | (5.69) | (3.97) | (4.84) | (3.87) | (4.56) | (3.88) | (4.60) | |
Education | 12.43 | 11.50 | 12.75 | 12.50 | 12.78 | 11.93 | 12.79 | 12.50 | 12.93 | 12.92 | 12.77 | 12.96 | 12.77 | 12.96 |
(2.58) | (0.71) | (2.72) | (2.00) | (2.70) | (2.62) | (2.72) | (2.77) | (2.89) | (3.01) | (2.97) | (3.28) | (2.97) | (3.28) | |
Gender (% w) | 47.6 | 0.0 | 37.5 | 37.5 | 36.7 | 35.7 | 40.4 | 33.3 | 43.1 | 44.0 | 41.7 | 40.7 | 41.7 | 40.7 |
MMSE | 29.24 | 29.00 | 29.10 | 29.00 | 29.10 | 28.86 | 29.25 | 28.56 | 29.02 | 28.96 | 28.70 | 28.63 | 28.83 | 27.92 |
(1.00) | (0.00) | (0.95) | (0.76) | (0.90) | (1.17) | (0.84) | (1.20) | (1.21) | (1.02) | (1.17) | (1.08) | (1.25) | (1.38) |
Visit 0 was defined as that visit at which the NC-MCI patients received a diagnosis of MCI. The last visit data from NC-NC participants were yoked to NC-MCI visit 0 such that groups were optimally matched according to demographic variables, and neuropsychological data were retrospectively modeled. NC-NC, cognitively healthy participants who remained healthy throughout the entire observation period; NC-MCI, initially healthy participants who progressed to MCI at Visit 0; Y, years; Dx, diagnosis; w, women; MMSE, Mini-Mental State Examination [30].