Table 5.

DNA methylation markers in bladder cancer associated with progression or recurrence in NMIBC

Genes	Progression	Recurrence	Study
APAF1	NA	0.05	Christoph et al, Int J Cancer, 2006
CDH13	0.00	0.01	Lin et al, Int Urol Nephrol, 2012
CDKN2A	NA	0.05	Lin et al, Urol Oncol, 2010
DAPK1	NA	0.001	Tada et al, Cancer Res, 2002
DAPK1	NA	0.04	Christoph et al, Int J Cancer, 2006
IGFBP3	NA	0.02	Christoph et al, Int J Cancer, 2006
RASSF1A	0.004	NA	Kim et al, Clin Genitourin Cancer, 2012
RASSF1A	0.04	NA	Catto et al, J Clin Oncol, 2005
RASSF1A, CDH1, APC, TNFSR25, EDNRB	0.05	NA	Yates et al, Clin Cancer Res, 2007
RUNX3	0.01	0.02	Kim et al, Cancer Res, 2005
RUNX3	0.006	0.04	Yan et al, J Surg Oncol, 2012
RUNX3	0.013	NA	Kim et al, J Urol, 2008
SYMPO2	0.05	NA	Cebrian et al, Cancer Res, 2008
SYMPO2	0.03	0.01	Alvarez-Mugica et al, J Urol, 2010
TBX2, TBX3, GATA2, ZIC4	0.003	NA	Kandimalla et al, Eur Urol, 2012
TBX4	0.05	NA	Reinert et al, Clin Cancer Res, 2011
TIMP3	NA	0.036	Friedrich et al, Eur J Cancer, 2005
TIMP3	0.01	NA	Hoque et al, JNCI, 2006