Table 3.

Sequence of cognitive decline for MMSE and ADAS-cog subscores by range of MMSE total score

AD Severity	Range of MMSE	MMSE subscore		ADAS-cog subscorea
	total score	Impairment start	Full impairment	Impairment start	Full impairment
Normal or very	30–27b	Recall;		Word recall task;
mild cognitive decline		Orientation in time		Delayed word recall;
				Orientation;
				Number cancellation (target hits)
Mild AD	26–21	Attention &Concentration (24);	Recall (22)	Constructional praxis (25)	Delayed word recall (21)
		Orientation in place (22);
		Language (22)
Moderate AD	20–15	Drawing (18)c	Drawing (18)c	Executive function (maze) (17);
				Language (15)
MS/S AD	14–11		Attention &Concentration (13);		Number cancellation (target hits) (11)
			Orientation in time (11)
	10–6	Registration (9)			Executive function (maze) (8);
					Word recall task (8); Orientation (6)
	5–0		Orientation in place (4);		Constructional praxis (2)
			Registration (1);		[Language]d
			[Language]d

Subscores are displayed in the AD severity group where the estimated probability of start/full impairment reaches 50%. For each subscore, the number in brackets is the MMSE total score when the subscore ≥ 50%. MMSE scores were available for 1,495 patients and ADAS-cog scores for 1,026 patients. ^aResults presented only for ADAS-cog subscores that correspond to the MMSE subscores. ^bPatients with MMSE >26 were not included in the study. The subscores listed in the shaded area have impairment start outside the observed data range but, based on the model data, impairment start will be at an MMSE total score >26. ^cDrawing subscore has a score range 0–1 (i.e., either no impairment or full impairment). ^dThe Language subscores given in square brackets did not cross 50% probability. AD, Alzheimer’s disease; MMSE, Mini-Mental State Examination; ADAS-cog, cognitive subscale of the Alzheimer’s Disease Assessment Scale; MS/S, moderately severe/severe.