Table 3.
Clinical correlates in 513 recent onset Parkinson’s disease with complete case data and only one non-motor feature
| Variable | Hyposmia only n = 375 (73.1%) | RBD only n = 83 (16.2%) | Constipation only n = 33 (6.4%) | Depression only n = 22 (4.3%) | Unadjusted p-value | Adjusted p-value |
| Age | 67.3 (7.8) | 70.4 (7.9) | 73.6 (9.3) | 70.1 (10.9) | <0.001 | <0.001a |
| Male Sex | 234 (62.4%) | 51 (61.4%) | 26 (78.8%) | 11 (50.0%) | 0.17 | 0.19b |
| Disease duration | 1.3 (0.9) | 1.4 (0.9) | 1.5 (0.9) | 1.2 (1.0) | 0.42 | 0.54c |
| UPDRS 3 | 20.6 (11.3) | 23.4 (12.7) | 25.1 (15.7) | 27.6 (15.1) | 0.008 | 0.073d |
| Motor subtype | ||||||
| TD | 200 (56.0%) | 37 (48.1%) | 13 (41.9%) | 10 (45.5%) | ||
| PIGD | 116 (32.5%) | 34 (44.2%) | 16 (51.6%) | 8 (36.4%) | 0.11 | 0.32d |
| Indeterminate | 41 (11.5%) | 6 (7.8%) | 2 (6.5%) | 4 (18.2%) | 0.64 | 0.62d |
| MoCA | ||||||
| Normal | 289 (82.1%) | 60 (80.0%) | 26 (81.3%) | 11 (52.4%) | 0.008 | 0.006d |
| MCI | 36 (10.2%) | 3 (4.0%) | 4 (12.5%) | 3 (14.3%) | ||
| Dementia | 27 (7.7%) | 12 (16.0%) | 2 (6.3%) | 7 (33.3%) | ||
| NMSS Total | 20.9 (14.9) | 26.7 (17.6) | 28.2 (15.8) | 58.0 (30.8) | <0.001 | <0.001d |
| Dopamine imaging performed | 85 (26.3%) | 18 (25.7%) | 11 (35.5%) | 7 (35.0%) | 0.60 | 0.34d |
Data are mean (standard deviation) or number (percentage). UPDRS 3 = Movement Disorder Society unified Parkinson’s disease rating scale, TD = tremor dominant, PIGD = postural instability gait difficulty, MoCA = Montreal cognitive assessment, MCI = mild cognitive impairment, NMSS = non motor symptom scale. aAdjusted for disease duration and sex, bAdjusted for age and disease duration, cAdjusted for age and sex, dAdjusted for age, sex and disease duration.