Figure 1.

Histological evaluation of cellular infiltration into the iris and ciliary bodies. Vel (L) = low-dose bortezomib, Vel (H) = high-dose bortezomib; inflammatory cell infiltration can be observed in the ciliary bodies of (b) LPS only and (c) low-dose bortezomib-treated rat eyes but not in (a) the control and (d) high-dose bortezomib-treated groups. Scale bar = 50 μm. (e) Quantification of the infiltrating cells in the AqH. EIU rats pretreated with bortezomib showed significantly reduced cell numbers in the AqH in a dose-dependent manner. The AqH was pooled from one eye of five rats in each group. The data are expressed as the means ± SDs of three independent experiments (bar graph). ^∗ p < 0.05 compared with the control group.