Figure 5.

Expression of iNOS, CAT-1, and CAT-2 proteins in the ICBs as assessed by western blotting. The proteins were isolated under control conditions (Ctrl), from rats injected with LPS (LPS), and from rats pretreated with low-dose bortezomib (VL) or high-dose bortezomib (VH). LPS induced the expression of iNOS and CAT-2 proteins in the ICBs of EIU rats. Pretreatment with bortezomib decreased their expression (a and c). There were no significant differences in CAT-1 protein levels among the four groups (b). As compared with the control group, the protein levels of IκB decreased in the LPS group and increased in the bortezomib treatment groups. The symbol “∗” indicates statistical significance.