Table 4.
Summary of previous publications reporting associations with SNPs that meet the p < 0.05 threshold in the current replication study
| Reference | Gene | SNP | N (n events) | Allelesa | Genotype counts | Model | HR (95% CI) | p | Directionally consistent replication in current study |
| Lee EK et al. [13] | RGS13 | rs3795617 | 421 NMIBC (232 R) | G/A | NR | ADD | 0.79 (0.65–0.96) | 0.019 | N |
| RGS4 | rs6678136 | 421 NMIBC (85 P) | G/A | NR | DOM | 2.07 (1.20–3.57) | 9.4×10–3 | Y | |
| RGS5 | rs11585883 | 421 NMIBC (85 P) | A/G | NR | DOM | 1.93 (1.12–3.32) | 0.018 | Y | |
| RGS5 | rs12035879 | 325 MIBC (144 OD) | G/A | NR | REC | 1.65 (1.02–2.66) | 0.039 | Y | |
| Gangawar R et al. | ERCC2 | rs1799793 | 74 BCG-NMIBC (35 R) | G/A | 31/28/15 | GENO | 0.64 (0.25–1.64) | 0.356 | Y |
| [16] | 3.07 (1.22–7.68) | 0.016 | |||||||
| Jaiswal PK et al. | IL18 | rs187238 | 78 BCG-NMIBC (34 R) | G/C | 36/39/3 | GENO | 2.35 (1.09–5.10) | 0.030 | Y |
| [17] | 2.43 (0.50–11.79) | 0.269 | |||||||
| Chen M et al. | SUFU | rs11594179 | 141 TUR-only-NMIBC | G/A | GG: 93 | DOM | 1.57 (1.00–2.45) | 0.05 | N |
| [8] | (92 R) | GA+AA: 48 | |||||||
| Andrew AS et al. | TERT | rs2075786 | 410 MIBC (172 OD) | T/C | 164/198/57 | GENO | 0.8 (0.6–1.1) | NR | Y |
| [22] | DOM | 0.5 (0.3–1.0) | (Logrank | ||||||
| 0.8 (0.5–1.0) | p = 0.1) |
aFirst allele is reference/major allele, and second allele is predictor/minor allele. Abbreviations: ADD: additive; BCG: bacillus Calmette-Guérin; CI: confidence interval; DOM: dominant; GENO: genotypic; HR: hazard ratio; MIBC: muscle-invasive or metastatic bladder cancer; NMIBC: non-muscle-invasive bladder cancer; NR: not reported; OD: overall death; P: progression; R: recurrence; REC: recessive; SNP: single nucleotide polymorphism; TUR: transurethral resection.