Table 1. Dose response for disease and intestinal colonization of rabbits by C. jejuni strains NCTC 11168 and ATCC 33560.
C. jejuni isolates | Dose of inocula (cfu)a | Diarrhea index | No. of C. jejuni-positive rabbit/total no. of rabbits by PCRb | Colonizationc | ||||
---|---|---|---|---|---|---|---|---|
jejunum | cecum | colon | jejunum | cecum | colon | |||
NCTC 11168 | 1010 | 1.61 | 4/4 | 4/4 | 4/4 | 5.08 ± 0.25 | 6.27 ± 0.23 | 6.04 ± 0.34 |
109 | 1.73 | 4/4 | 4/4 | 4/4 | 5.30 ± 0.13 | 6.62 ± 0.21 | 6.09 ± 0.87 | |
108 | 0.83 | 3/4 | 4/4 | 4/4 | 2.62 ± 2.27 | 4.55 ± 0.17 | 3.51 ± 0.91 | |
107 | 0.4 | 2/4 | 4/4 | 3/4 | 1.31 ± 1.18 | 2.64 ± 0.48 | 2.64 ± 0.84 | |
106 | 0.4 | 2/4 | 4/4 | 4/4 | 0.13 ± 0.22 | 2.79 ± 0.14 | 2.29 ± 0.43 | |
105 | 0 | 2/4 | 2/4 | 2/4 | 0 ± 0 | 0.78 ± 1.11 | 0.61 ± 0.86 | |
104 | 0 | 1/4 | 3/4 | 3/4 | 0 ± 0 | 1.22 ± 0.67 | 1.43 ± 0.48 | |
103 | 0 | 0/4 | 2/4 | 1/4 | 0 ± 0 | 0 ± 0 | 0 ± 0 | |
102 | 0 | 1/4 | 2/4 | 1/4 | 0 ± 0 | 0 ± 0 | 0 ± 0 | |
ATCC 33560 | 1010 | 0.35 | 2/4 | 4/4 | 3/4 | 1.80 ± 1.56 | 4.00 ± 0.41 | 3.52 ± 0.30 |
108 | 0 | 2/4 | 4/4 | 1/4 | 1.19 ± 1.03 | 3.25 ± 0.60 | 0.74 ± 1.28 | |
106 | 0 | 1/4 | 2/4 | 2/4 | 0.84 ± 1.46 | 2.13 ± 1.84 | 2.22 ± 1.93 |
aRabbits were euthanized at 24 h postinoculation.
bAll control animals were negative for C. jejuni by culture and PCR.
cMean ± SD (n = 3) log10 CFU/g.