Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Jun 30;6:28938. doi: 10.1038/srep28938

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2016, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PMC Copyright notice

(A) Representative current traces, taken from an OFF-GC, showing that during perfusion of PPADS (100 μM) and suramin (Sur) (50 μM), application of ATP (100 μM) no longer suppressed the glycine current. (B) Current traces of an OFF-GC, showing that in the presence of Evans blue (200 μM), 100 μM ATP still suppressed the glycine current. (C,D) Representative recordings obtained from two different OFF-GCs, showing that in the presence of 2 μM MRS2500 (C) or 50 μM NF157 (D), ATP persisted to suppress the glycine currents. Note that extracellular application of 2 μM MRS2500 per se suppressed the current (C), and the ATP-induced suppression of glycine currents was partially attenuated by MRS2500/NF157. (E,F) Current traces of two different OFF-GCs, showing that application of 100 μM MRS2365 (E) or 10 μM NF546 (F) suppressed the glycine currents. Each bar chart in A-F shows the statistical analysis of the data. ***P < 0.001 vs. control (B,E,F); **P < 0.01, as compared to the current amplitudes before ATP application (C,D).