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. 2016 Jun 28;60:10.3402/fnr.v60.31288. doi: 10.3402/fnr.v60.31288

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© 2016 Sheng Li et al.

This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for any purpose, even commercially, provided the original work is properly cited and states its license.

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Fig. 1 — Identification of apigenin as an inhibitor of 26S proteasome in HEK293A-luciferase-cODC cells. (a) Chemical structure of apigenin. (b) HEK293A-luciferase-cODC cells were seeded in 96-well plates and treated in the presence of indicated concentrations of apigenin or bortezomib for 3 h. (c) Concentration–response curve for apigenin. The calculated EC₅₀ value was 4.08 µM. (d) HEK293A-luciferase-cODC cells were seeded in 96-well plates and treated with 10 µM apigenin for the indicated time, or treated with 1 µM MG132 for 4 h. Results are representative of three separate experiments. The error bars represent the standard deviation of the measurements. (*) p<0.05, (**) p<0.01, (***) p<0.001 compared to the DMSO control.