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. 2016 Jun 30;6:28614. doi: 10.1038/srep28614

Figure 2. The R137Q mutation results in small embryos and embryonic lethality.

Figure 2

(a) Pol β R137Q embryos were found to be smaller than WT embryos at E15.5 and E17.5. In addition, some R137Q embryos were dead. (b) The average embryo weights at E15.5, E17.5 and E19.5 show that R137Q embryos developed at a slower rate compared to WT embryos. The data represent the mean ± SD of seven to ten embryos (**P < 0.01, ***P < 0.001, Student’s t-test). (c) Approximately 21% of R137Q embryos were dead. The data represent the mean ± SD of embryos from eight pregnant mice (embryo numbers: WT = 54, R137Q = 41) (**P < 0.01, Student’s t-test).