Table 3.
Alleles and genotypes of the ADAM10 SNPs in the cases and controls of cohorts I + II.
| Cases n (%) | Controls n (%) | ORs (95% CI) | p Values | q Values | |
|---|---|---|---|---|---|
| rs653765 G > A | |||||
| G/A | 832 (83.8)/160 (16.4) | 874 (82.8)/182 (17.2) | 1.07 (0.85–1.35) | 0.582 | 4.656 |
| GG/GA/AA | 348 (70.2)/136 (27.4)/12 (2.4) | 363 (68.7)/148 (28.0)/17 (3.2) | 1.07 (0.85–1.35) | 0.581 | 4.647 |
| GG/GA + AA | 348 (70.2)/148 (29.8) | 363 (68.7)/165 (31.3) | 1.05 (0.80–1.38) | 0.716 | 5.725 |
| GG + GA/AA | 484 (97.6)/12 (2.4) | 511 (96.8)/17 (3.2) | 1.33 (0.63–2.81) | 0.459 | 3.673 |
| rs514049 A > C | |||||
| A/C | 949 (95.7)/43 (4.3) | 968 (91.7)/88 (8.3) | 1.97 (1.35–2.87) | 0.000 | 0.003 |
| AA/AC/CC | 459 (92.5)/31 (6.3)/6 (1.2) | 448 (84.9)/72 (13.6)/8 (1.5) | 2.01 (1.29–3.11) | 0.002 | 0.016 |
| AA/AC + CC | 459 (92.5)/37 (7.5) | 448 (84.8)/80 (15.2) | 2.18 (1.44–3.29) | 0.000 | 0.002 |
| AA + AC/CC | 490 (98.8)/6 (1.2) | 520 (98.5)/8 (1.5) | 1.24 (0.43–3.59) | 0.697 | 5.576 |
ORs and p values have been adjusted for gender and age; q values were obtained using Bonferroni correction.