Figure 2. Dependence of EV71:TLLmv infection severity on the dose, age, and inoculation route.

(A) Kaplan-Meier survival curve of 1-week-old mice inoculated I.P. with different doses of EV71:TLLmv. (B) Age and inoculation route dependence of survival of mice inoculated with 10⁶ CCID₅₀ virus. (C,D) Kaplan-Meier survival curves of mice inoculated with 10⁶ CCID₅₀ virus via I.P. (C) or I.M. (D) route. Deaths recorded were a result of disease or euthanasia at moribund stage. Mean duration of survival were compared using Mantel-Cox log-rank test. **p < 0.005; ***p < 0.0005; ****p < 0.0001. Mock. Sham-inoculated controls; wo, mouse age in weeks.