Figure 3. Clinical presentation of EV71:TLLmv infection in 1-week-old mice.
Mice inoculated with 106 CCID50 virus by I.P. (A) or I.M. (B) injection were grouped into four categories based on clinical signs observed throughout the observation period. Severely infected mice (both Class-I and Class-II) exhibited flaccid paralysis (C), either in the forelimbs (yellow arrows), hind limbs (red arrows), or both; and hairless lesions (green arrows) (D) that persisted for several days and typically disappeared within 1 week. A few Class-I mice also exhibited haemorrhagic lesions in the hind feet (E), which appear to be due to vasculitis (blue arrows).