Table 1. Clinical features of EV71:TLLmv-infected BALB/c mice at the time of euthanasia.

	Class-IA	Class-IB	Class-II	Survivorsa
Time to onset of signs [days post-infection; DPI]	Within 3–5 DPI	Within 3–7 DPI	>7 DPI	N/Ab
Level of consciousness	Stuporc/Comad	Stuporc	Active	Active
Weight loss	<20% body weight	<20% body weight	>20% body weight	None or <20% body weight
Limb function (>48 h)	Spastic limb paresis/paralysis	Spastic limb paresis/paralysis	Flaccid limb paralysis	Normal
Breathing function	Tachypnea /gasping/hiccupping	Regular	Regular	Regular
Cardiac function	Tachycardia	Tachycardiae/Regular	Regular	Regular
Limb tremors	May be present	May be present	Absent	Absent

^aAnimals were assessed at the end of the observation period (28 DPI).

^bNot Applicable.

^cAnimal was unable to self-right, but responded to physical stimulation of the toes.

^dAnimal was unable to self-right and did not respond to physical stimulation of the toes.

^eTachycardia was observed in 35% of Class IB mice.