Figure 4. pVAX-sTat-IMX313 vaccinated mice exhibit superior control against EcoHIV challenge.
Unvaccinated mice or vaccinated mice which received 5 doses of 50 μg of either pVAX-sTat or pVAX-sTat-IMX313 were challenged with 1.5 μg p24 of EcoHIV/NL4-3 10 days post final vaccination. The viral load in PECs and splenocytes was determined by qRT-PCR; EcoHIV RNA levels in (A) PECs and (B) splenocytes 7 days post challenge. EcoHIV mRNA levels were normalised to RPL13a mRNA and the data represent the mean (n = 7) ± SEM. **p < 0.05 and **p ≤ 0.01(Mann–Whitney U test).
