Table 2.
Association between CASP7 rs10553596 and AD/dementia status in APOE ε4 allele carriers (A), and non-APOEε 4 allele carriers (B), stratified by ethnicity in Mount Sinai Biobank
| A. Carriers: Overall P-value = 0.031, OR = 0.56 (95 % CI 0.00–0.94) | |||||
| Ethnicity | Phenotype | Ref-Ref | Alt-* | P-value | Odds Ratio |
| European | Controls | 137 | 141 | 0.25 | 0.49 |
| AD/dementia | 6 | 3 | |||
| African | Controls | 68 | 145 | 0.19 | 0.54 |
| AD/dementia | 7 | 8 | |||
| Hispanic | Controls | 155 | 146 | 0.12 | 0.56 |
| AD/dementia | 17 | 9 | |||
| B. Non-Carriers: Overall P-value = 0.060, OR = 0.77 (95 % CI 0.00–1.01) | |||||
| Ethnicity | Phenotype | Ref-Ref | Alt-* | P-value | Odds Ratio |
| European | Controls | 588 | 637 | 0.43 | 0.83 |
| AD/dementia | 10 | 9 | |||
| African | Control | 233 | 453 | 0.24 | 0.74 |
| AD/dementia | 14 | 20 | |||
| Hispanic | Control | 867 | 731 | 0.17 | 0.80 |
| AD/dementia | 62 | 42 | |||