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. 2016 Jun 23;17(Suppl 2):397. doi: 10.1186/s12864-016-2726-y

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© Martelli et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Relation between the per-protein fraction of non-perturbing, solvent accessible variations and the corresponding number of the wild-type partners of interactions in the human interactome. The box-plot reports the median and the lower and upper quartiles of the number of interactions present in IntAct as a function of the fraction of solvent accessible, non-perturbing variations. The dashed blue line connects the average values. Non perturbing variations are those predicted to promote a |ΔΔG| ≤ 1 kcal/mol with INPS3D and found in protein sites that are solvent accessible. Data refers to 170 proteins with 4037 variations of our data set. Proteins with less than 5 disease-related variations or without interactomic data reported in IntAct are excluded