Fig. 2.

Selection magnitude for affinity loss and gain of ETS, FOX and C/EBP motifs in different cancer types. X-axis displays the selection magnitude for motif affinity loss (a) or gain (b) caused by somatic mutations. Box-plots are provided for ETS-related (14 motifs), FOX (13 motifs), C/EBP-related (9 motifs) and NR3 (Steroid hormone receptors, 11 motifs) transcription factor families in three cancer types with the largest numbers of mutation calls. In particular, C/EBP motifs display frequent affinity loss in breast cancer, FOX and NR3 motifs are protected from both the affinity loss and gain in lung adenocarcinoma and breast cancer, and ETS motifs tend to emerge in all three cancer types (breast, lung and liver). Data for two control datasets (shuffle, genomic) are shown