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. Author manuscript; available in PMC: 2016 Jun 30.
Published in final edited form as: Curr Opin Investig Drugs. 2005 Aug;6(8):845–853.

Table 5.

Pharmacokinetic parameters of single-dose SPK-843.

Pharmacokinetic
parameter		 SPK-843 concentration
0.0625 mg/kg 0.125 mg/kg 0.25 mg/kg 0.5 mg/kg
Cmax (µg/ml) 0.519 ± 0.057 1.07 ± 0.1 1.65 ± 0.21 2.36 ± 0.32
AUC (µg.h/ml) 17.2 ± 4 36.1 ± 7.9 71.8 ± 15.1 129 ± 12
t1/2 (h) 55.2 ± 11.3 65.4 ± 6.6 105 ± 17 124 ± 22
CL (ml/h/kg) 3.78 ± 0.57 3.59 ± 0.7 3.63 ± 0.82 3.9 ± 0.36
Vss 268 ± 30 307 ± 54 494 ± 38 654 ± 120

CL clearance, t1/2 half-life, Vss steady-state volume of distribution.