Study Type	Result	Reference
Synthesis.	Partricin A was modified to generate analogs. Most of the amide derivates were more potent antifungals, less toxic and produced less hemolysis than amphotericin B. Two analogs were selected for further development, SPA-S-710 and SPA-S 752. SPA-S-753 is the diaspartate salt of SPA-S-752 and SPK-843 is the diascorbate salt.	586047
Photostability.	Light induced the formation of the E isomer. Violet and ultraviolet radiation yielded damaging effects. The light emitted by red varnished wire lamps was much less damaging than the light of usual wire, neon and sodium lamps. Lowering the light emission in the violet and ultraviolet regions reduced photodegradation.	291454
Stability.	Intralipid 10% emulsion containing SPK-843 (0.1 to 0.5 mg/ml) at mildly acid or basic pH was physically stable. SPK-843 in Intralipid 10% emulsion, at natural and mildly basic pH, was chemically stable for 2 h at 25°C even in a well-lit room.	440552