Table 3.
HIV-1 and AIDS Opportunistic Infections Data for Manzaminesa
| compound | activity IC50 (μg/mL)
|
||||
|---|---|---|---|---|---|
| S. aureus | MRS | C. neoformans | M. intracellulare | HIV-1 EC50 (μM) | |
| manzamine A (2) | 0.5 | 0.7 | 3.0 | 0.35 | 4.2 |
| 8-hydroxymanzamine A (6) | 0.9 | 4.0 | 3.0 | 1.0 | 0.59 |
| manzamine A N-oxide (5) | 0.5 | 0.4 | 1.0 | 0.2 | NT |
| 3,4-dihydromanzamine A N-oxide | NA | NA | NA | NA | NA |
| 12,34-oxamanzamine E (3) | NA | NA | NA | NA | NT |
| manzamine E (7) | NA | NA | NA | 12.5 | 13.1 |
| 6-hydroxymanzamine E (8) | NT | NT | 5.5 | 3.5 | NT |
| manzamine F (9) | NA | NA | 6.5 | 6.25 | 7.3 |
| manzamine J (1) | NA | NA | NA | 15 | NT |
| 8-hydroxymanzamine J (4) | 3.0 | 5.0 | 3.5 | 0.45 | NT |
| 6-deoxymanzamine X | 1.5 | 1.5 | 2.0 | 6.25 | 1.6 |
| manzamime X | 1.0 | 0.75 | 3.0 | 1.5 | 2.3 |
| neo-kauluamine | NA | NA | 3.0 | 3.0 | 2.3 |
| ircinal A | NA | NA | NA | 50 | 6.8 |
| ircinol A (10) | NA | 30 | NA | 50 | 4.3 |
| amphotericin B | NT | NT | 0.15 | NT | NT |
| ciprofloxacin | 0.10 | 0.10 | NT | 0.25 | NT |
a
NA = not active. NT = not tested.