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. Author manuscript; available in PMC: 2016 Jun 30.
Published in final edited form as: Chem Rev. 2007 Dec 21;108(1):264–287. doi: 10.1021/cr078199m

Scheme 5.

Scheme 5

Synthesis of Lamellarins K (12) and L (15)a

a Reagents and conditions: (i) NaHCO3, 125, CH3CN, reflux, 70% (126), 70% (127); (ii) H2, Pd/C, EtOAC; (iii) NaH, THF, 93% (12, over 2 steps), 87% (15, over 2 steps). (Reprinted with permission from ref 43. Copyright 2004 by John Wiley & Sons, Inc.)