Table 3.

Annual Incidence of Severe Hypoglycemia in Adults With T1DM.

Study	Population	Design	Number of severe hypoglycemic events per patient-year
MacLeod et al, 19938	544 randomly selected adult patients with T1DM attending a diabetes outpatient clinic in a teaching hospital	Retrospective patient questionnaire covering past year	1.7
ter Braak et al, 200010	195 consecutive adult patients with T1DM attending a diabetes outpatient clinic at an academic medical center	Retrospective patient questionnaire covering past year	1.5
Pedersen-Bjergaard et al, 20049	1076 consecutive adult patients with T1DM attending a clinical at a Danish general hospital	Retrospective patient questionnaire covering past year	1.3
Donnelly et al, 20057	77 adults with T1DM recruited from a population-based diabetes register in Tayside, Scotland	Prospective patient diary recording of events occurring over 1 month	1.15
UK Hypoglycaemia Study Group, 200711	107 adults with T1DM recruited from 6 secondary care diabetes centers	Prospective patient diary recording of events occurring over 9-12 months	1.1 (T1DM duration <5 years) 3.2 (T1DM duration >15 years)
Khunti et al, 201457	8022 adults with T1DM from 24 countries consecutively enrolled during a routine clinical consultation	Retrospective (6 months) patient questionnaire and prospective (4 weeks) patient questionnaire	2.1 (retrospective) 4.9 (prospective)
Weitgasser and Lopes, 201512	222 adults with T1DM recruited from online panel representative of general diabetes population	Retrospective patient questionnaire covering past year	0.7
Giorda et al, 201556	206 consecutive adults with T1DM seen and 18 diabetes clinics	Retrospective patient questionnaire covering past year	0.49

In all studies, severe hypoglycemia was defined as episodes of hypoglycemia requiring assistance from others for recovery.