Table 3.
Study | Population | Design | Number of severe hypoglycemic events per patient-year |
---|---|---|---|
MacLeod et al, 19938 | 544 randomly selected adult patients with T1DM attending a diabetes outpatient clinic in a teaching hospital | Retrospective patient questionnaire covering past year | 1.7 |
ter Braak et al, 200010 | 195 consecutive adult patients with T1DM attending a diabetes outpatient clinic at an academic medical center | Retrospective patient questionnaire covering past year | 1.5 |
Pedersen-Bjergaard et al, 20049 | 1076 consecutive adult patients with T1DM attending a clinical at a Danish general hospital | Retrospective patient questionnaire covering past year | 1.3 |
Donnelly et al, 20057 | 77 adults with T1DM recruited from a population-based diabetes register in Tayside, Scotland | Prospective patient diary recording of events occurring over 1 month | 1.15 |
UK Hypoglycaemia Study Group, 200711 | 107 adults with T1DM recruited from 6 secondary care diabetes centers | Prospective patient diary recording of events occurring over 9-12 months | 1.1 (T1DM duration <5 years) 3.2 (T1DM duration >15 years) |
Khunti et al, 201457 | 8022 adults with T1DM from 24 countries consecutively enrolled during a routine clinical consultation | Retrospective (6 months) patient questionnaire and prospective (4 weeks) patient questionnaire | 2.1 (retrospective) 4.9 (prospective) |
Weitgasser and Lopes, 201512 | 222 adults with T1DM recruited from online panel representative of general diabetes population | Retrospective patient questionnaire covering past year | 0.7 |
Giorda et al, 201556 | 206 consecutive adults with T1DM seen and 18 diabetes clinics | Retrospective patient questionnaire covering past year | 0.49 |
In all studies, severe hypoglycemia was defined as episodes of hypoglycemia requiring assistance from others for recovery.