Table 6.
Estimated power and LOD score threshold based on 10,000 simulation replicates for F2 intercross between CSS-19A and CSS-19PWDa
| Number of male F2 animals (LOD threshold)b | Genotype datac | Position of additive QTL(s): at length of MMU19 (≈ cM) | Power | |||
|---|---|---|---|---|---|---|
| ¼ (≈14.6) | ½ (≈29.2) | ¾ (≈43.7) | Markers (24) equally spaced | Randomly positioned markers (24) | ||
| Average spacing = 2.5 cM | Average spacing = 2.5 cM | |||||
| Maximum spacing = 2.5 cM | Maximum spacing = 7.5 cM | |||||
| N = 33 | Error-free / complete | + | – | – | 0.5489 | 0.5593 |
| (2.4520) | 1 % G / 5 % M | + | – | – | 0.5613 | 0.5574 |
| Error-free / complete | – | + | – | 0.5528 | 0.5657 | |
| 1 % G / 5 % M | – | + | – | 0.5695 | 0.5422 | |
| Error-free /complete | – | – | + | 0.5453 | 0.5585 | |
| 1 % G / 5 % M | – | – | + | 0.5663 | 0.5438 | |
| Error-free /complete | + | + | – | 0.3129 | 0.3227 | |
| 1 % G / 5 % M | + | + | – | 0.3363 | 0.3142 | |
| Error-free / complete | + | – | + | 0.3027 | 0.2993 | |
| 1 % G / 5 % M | + | – | + | 0.3087 | 0.3003 | |
| Error-free / complete | – | + | + | 0.3296 | 0.3303 | |
| 1 % G / 5 % M | – | + | + | 0.3454 | 0.3078 | |
| N = 66 | Error-free / complete | + | – | – | 0.9122 | 0.9102 |
| (2.3497) | 1 % G / 5 % M | + | – | – | 0.9118 | 0.8958 |
| Error-free / complete | – | + | – | 0.9078 | 0.9100 | |
| 1 % G / 5 % M | – | + | – | 0.9128 | 0.8838 | |
| Error-free / complete | – | – | + | 0.9086 | 0.9128 | |
| 1 % G / 5 % M | – | – | + | 0.9152 | 0.8920 | |
| Error-free / complete | + | + | – | 0.6511 | 0.6513 | |
| 1 % G / 5 % M | + | + | – | 0.6556 | 0.6097 | |
| Error-free / complete | + | – | + | 0.5973 | 0.5823 | |
| 1 % G / 5 % M | + | – | + | 0.6076 | 0.5513 | |
| Error-free / complete | – | + | + | 0.6516 | 0.6410 | |
| 1 % G / 5 % M | – | + | + | 0.6599 | 0.6025 | |
| N = 99 | Error-free / complete | + | – | – | 0.9885 | 0.9891 |
| (2.3321) | 1 % G / 5 % M | + | – | – | 0.9898 | 0.9874 |
| Error-free / complete | – | + | – | 0.9871 | 0.9867 | |
| 1 % G / 5 % M | – | + | – | 0.9878 | 0.9867 | |
| Error-free / complete | – | – | + | 0.9898 | 0.9873 | |
| 1 % G / 5 % M | – | – | + | 0.9887 | 0.9892 | |
| Error-free / complete | + | + | – | 0.8551 | 0.8351 | |
| 1 % G / 5 % M | + | + | – | 0.8511 | 0.8434 | |
| Error-free / complete | + | – | + | 0.7865 | 0.7878 | |
| 1 % G / 5 % M | + | – | + | 0.7958 | 0.7938 | |
| Error-free / complete | – | + | + | 0.8427 | 0.8402 | |
| 1 % G / 5 % M | – | + | + | 0.8564 | 0.8456 | |
| N = 132 | Error-free / complete | + | – | – | 0.9989 | 0.9987 |
| (2.3086) | 1 % G / 5 % M | + | – | – | 0.9990 | 0.9983 |
| Error-free / complete | – | + | – | 0.9988 | 0.9988 | |
| 1 % G / 5 % M | – | + | – | 0.9990 | 0.9986 | |
| Error-free / complete | – | – | + | 0.9993 | 0.9982 | |
| 1 % G / 5 % M | – | – | + | 0.9990 | 0.9993 | |
| Error-free / complete | + | + | – | 0.9466 | 0.9413 | |
| 1 % G / 5 % M | + | + | – | 0.9447 | 0.9446 | |
| Error-free / complete | + | – | + | 0.9118 | 0.9057 | |
| 1 % G / 5 % M | + | – | + | 0.9110 | 0.9069 | |
| Error-free | – | + | + | 0.9427 | 0.9423 | |
| 1 % G / 5 % M | – | + | + | 0.9479 | 0.9399 | |
a The genetic length of male mouse chromosome 19 is 58.309 cM [49]
b Estimate of the 5 % LOD threshold
c ‘1 % G / 5 % M’ means 1 % genotyping errors and 5 % missing data