Table 4.
Pulmonary mRNA expression levels in mice, 1, 3 and 28 days post-exposure to 54 μg, 162 μg and 486 μg sanding dust from epoxy and 162 μg CB
| Control | EPOXY-REF | EPOXY-CNT | EPOCYL | CB | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 day | 0 μg | 54 μg | 162 μg | 486 μg | 54 μg | 162 μg | 486 μg | 54 μg | 162 μg | 486 μg | 162 μg |
| Il-6 | 0.08 ± 0.02 | 0.31 ± 0.19 | 1.19 ± 0.31*** | 2.33 ± 0.53*** | 1.45 ± 0.87** | 2.32 ± 0.97*** | 1.91 ± 0.50*** | 0.26 ± 0.10* | 2.43 ± 0.09*** | 1.35 ± 0.35*** | 0.21 ± 0.07 |
| Hmox-1 | 5.26 ± 0.62 | 5.98 ± 1.5 | 13.8 ± 3.0 | 19.2 ± 2.7** | 25.6 ± 10.2 | 28.9 ± 4.9** | 17.2 ± 2.6* | 6.85 ± 1.7 | 17.6 ± 3.8 | 15.6 ± 3.4 | 6.22 ± 0.89 |
| 3 days | |||||||||||
| Il-6 | 0.07 ± 0.01 | 0.11 ± 0.03 | 0.51 ± 0.11** | 0.6 ± 0.18*** | 0.11 ± 0.03 | 0.33 ± 0.15 | 0.90 ± 0.30 | 0.14 ± 0.07 | 0.25 ± 0.07 | 4.00 ± 1.28*** | 0.29 ± 0.11 |
| Hmox-1 | 3.95 ± 0.72 | 4.07 ± 0.75 | 5.28 ± 1.3 | 6.47 ± 1.7 | 5.41 ± 1.5 | 9.11 ± 2.5 | 14.2 ± 5.7 | 7.32 ± 2.2 | 7.74 ± 2.6 | 28.3 ± 7.7 | 5.84 ± 1.45 |
| 28 days | |||||||||||
| Il-6 | 0.24 ± 0.05 | 0.13 ± 0.03 | 0.21 ± 0.10 | 0.25 ± 0.08 | 0.15 ± 0.08 | 0.14 ± 0.05 | 0.17 ± 0.07 | 0.15 ± 0.03 | 0.11 ± 0.03 | 0.33 ± 0.11 | 0.21 ± 0.05 |
| Hmox-1 | 4.95 ± 0.72 | 5.46 ± 1.3 | 9.33 ± 2.0 | 7.72 ± 1.3 | 3.40 ± 0.84 | 7.00 ± 2.3 | 7.38 ± 2.5 | 6.63 ± 1.0 | 5.70 ± 0.40 | 12.9 ± 1.04 | 4.87 ± 1.6 |
Normalised mRNA expression level of Il-6 and Hmox-1 (Mean ± SEM)
There were no statistically significant differences between the three sanding dusts at the 0.05 level
*p < 0.05 compared to controls, **p < 0.01 compared to controls, ***p < 0.001 compared to controls