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. 2016 Jun 30;7:280. doi: 10.3389/fphys.2016.00280

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Copyright © 2016 Martínez-Herrero, Larrayoz, Ochoa-Callejero, Fernández, Allueva, Ochoa and Martínez.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Small molecule 16311 prevents bone loss. Female mice were ovariectomized (OVX) or Sham operated (Sham) and then treated for 5 weeks with PBS (as a vehicle) or with 20 nmols/kg of small molecule 16311 dissolved in PBS, and the bone density of their femurs was measured by microCT (expressed as BV/TV) (n = 10 female mice/group). As expected, untreated ovariectomized mice suffered a significant bone loss when compared to Sham females (^**p < 0.01). On the other hand, ovariectomized females treated with 16311 had undistinguishable density from Sham controls (p>0.05) and significantly more bone density than untreated ovariectomized females (^#p < 0.05). Each bar represents the mean ± SD of all mice (n = 10 per group).