Table 3.
Toxicity analysis in the blood of ovariectomized (OVX) mice treated and untreated with 16311.
| OVX + PBS | OVX + 16311 | ||
|---|---|---|---|
| Biochemistry | Urea (mg/dL) | 18.21 ± 3.33 | 18.50 ± 3.78 |
| Creatinine (mg/dL) | 0.13 ± 0.01 | 0.13 ± 0.02 | |
| ALT (IU/L) | 39.52 ± 2.33 | 42.80 ± 7.08 | |
| AST (IU/L) | 92.00 ± 5.62 | 82.20 ± 7.75 | |
| ALKP (IU/L) | 40.03 ± 34.27 | 43.60 ± 35.63 | |
| GGT (IU/L) | 1.14 ± 0.58 | 0.56 ± 0.36 | |
| Hemogram | MCV (%) | 31.40 ± 0.33 | 30.58 ± 0.31 |
| RBC (106/μL) | 7.66 ± 0.08 | 7.46 ± 0.09 | |
| Hb (g/dL) | 12.18 ± 0.15 | 11.78 ± 0.17 | |
| WBC (103/μL) | 6.10 ± 0.64 | 4.96 ± 0.68 |
Values are the mean ± SEM of all animals in the group (n = 10 per group). All numbers are within normal values for C57BL/6 mice.