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. 2016 Jun 29;9:22. doi: 10.1186/s13040-016-0101-9

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© The Author(s) 2016

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Schematic of PCA based unsupervised FE. In gene expression analyses (top left), limited genes (red) exhibit periodic motion. After gene embedding (top right), genes exhibiting periodic motion (red crosses) are identified as outliers if the BH criterion adjusted P-values are lower than 0.01 (or 0.05) assuming that the PC score attributed to each gene obeys Gaussian distribution. This is because PC loading attributed to each sample exhibits periodic motion (bottom)