Table 1.
Challenge results in control and vaccinated sheep with live and inactivated Romanian SPPV vaccine. Antibody neutralizing titers of vaccinated sheep obtained before challenge. The infectious titer represents the maximum value obtained between day 6 and 8 post challenge
| Vaccine | Animals | Hypersensitivity titer in TCID50 | Antibody neutralizing titers in log10 | Infectious titer (ID50/ml) | Protection value | ||||
|---|---|---|---|---|---|---|---|---|---|
| Per animal | Group average | Per animal | Group average | Per animal | Group average | Per animal | Group average | ||
| Control animals | 299 | 0 | 0 | 0 | 0 | 5.2 | 5,4(a) | 0 | 0(a) |
| 277 | 0 | 0 | 5.6 | 0 | |||||
| Live SPPV vaccine | 977 | 1,6 | 1,6 | 1,9 | 1,7 | 1,5 | 0,75(b) | 3,9 | 4,6(b) |
| 928 | 1,6 | 1,26 | 0,5 | 4,9 | |||||
| 934 | 1,4 | 1,98 | 0,5 | 4,9 | |||||
| 999 | 1,8 | 1,5 | 0,5 | 4,9 | |||||
| Inactivated SPPV vaccine | 948 | 2,7 | 2,2 | 1,98 | 2,2 | 2,1 | 1,4 (b) | 3,3 | 4 (b) |
| 941 | 0 | 2,22 | 2,5 | 2,9 | |||||
| 949 | 4,5 | 2,46 | 0,5 | 4,9 | |||||
| 397 | 1,1 | 1,98 | 0,5 | 4,9 | |||||
| 398 | 2,5 | 2,46 | 0,5 | 4,9 | |||||
| 998 | 0,9 | 1,74 | 0,5 | 4,9 | |||||
| 973 | 4,5 | 2,46 | 0,5 | 4,9 | |||||
| 969 | 1,5 | 2,7 | 4,1 | 1,3 | |||||
(a–b) indicate a significant difference in means of infectious titers and protection values between vaccinated and unvaccinated animals and between G1 and G2 at the 0.05 level